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Lilly’s daily
Foundayo (orforglipron): cost, doses, results and how it compares
By the NexLife Medical Team · Medically reviewed by Adam Kennah, MD · Updated
Foundayo (orforglipron) is Lilly’s once-daily
- Self-pay: $149 to $299 a month at LillyDirect
- Once a day, with or without food, Lilly says
- Six doses: 0.8 mg to start, up to 17.2 mg
Foundayo at a glance
- What it is
- Lilly’s once-daily
GLP-1 pill (orforglipron) - FDA-approved
- April 1, 2026, for weight management
- Self-pay price
- $149 to $299 a month at LillyDirect
- With insurance
- As low as $25 a month; $50 on Medicare’s
GLP-1 Bridge - Doses
- Six: 0.8 mg to start, up to 17.2 mg
Lilly’s prices, read November 1, 2026. Comparing pills and shots? Call or text
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Compounded medicines aren’t FDA-approved. A NexLife provider prescribes one only if it offers a significant difference for you compared with an FDA-approved medicine.
Cost
How much does Foundayo cost without insurance?
| Dose | Self-pay price | Note |
|---|---|---|
| 0.8 mg | $149 | Starting dose |
| 2.5 mg | $149 | Temporarily reduced through December 31, 2026 |
| 5.5 mg | $199 | Temporarily reduced through December 31, 2026 |
| 9 mg | $299 | |
| 14.5 mg | $299 | If you refill within 45 days |
| 17.2 mg | $299 | If you refill within 45 days |
From Lilly’s LillyDirect page, read November 1, 2026. A month is 30 days. Self-pay only; medication alone. For 14.5 mg and 17.2 mg, $299 is the Foundayo Self-Pay Journey Program price and regular prices apply if you don’t refill within 45 days; at launch, The New York Times and CNBC reported that regular price as $349.
With commercial insurance that covers it, Lilly’s savings card can bring Foundayo to as little as $25 for a 1-, 2- or 3-month supply (government plans excluded). On Medicare Part D, eligible enrollees can get it for $50 a month through the
“…the Medicare GLP-1 Bridge will operate between July 1, 2026, and December 31, 2027.”
Centers for Medicare & Medicaid Services, Medicare GLP-1 Bridge
- Tell us about you About 3 minutes of health questions
- A licensed provider decides You’re prescribed only if it’s right for you
- Your partner pharmacy ships Usually within 1 to 2 business days, free
Key takeaways
- Foundayo (orforglipron) is Lilly’s once-daily
GLP-1 pill: $149 to $299 a month self-pay (checked November 1, 2026). - FDA-approved April 1, 2026. No food or water rules: Lilly says it can be taken any time, with or without food.
- Refill on time: at 14.5 mg and 17.2 mg, the $299 price holds only if you refill within 45 days.
- With commercial coverage, Lilly’s savings card can bring it to as little as $25; on Medicare’s
GLP-1 Bridge, $50 a month. - In the ATTAIN-1 trial, people who stayed on the highest dose lost 12.4% of their weight on average over 72 weeks.
- Prefer a weekly shot? Compounded semaglutide at NexLife (not FDA-approved) is $119 a month on the 12-month plan, at every dose.
The basics
What is Foundayo?
Foundayo (orforglipron, said fown-DAY-oh) is a once-daily
“Foundayo is a glucagon-like peptide-1 (GLP-1) receptor agonist in tablet form that should be taken orally once daily.”
U.S. Food and Drug Administration, FDA Approves First New Molecular Entity Under National Priority Voucher Program
Unlike Wegovy, Ozempic and Zepbound, which are peptides, Foundayo is a small molecule. Lilly says it’s the only
Once a day
Swallowed whole, with or without food. Not more than one tablet a day.
Six doses
0.8 mg to start, then 2.5, 5.5, 9, 14.5 and 17.2 mg, as your provider directs.
Prescription only
A provider decides if it’s right for you, and LillyDirect’s pharmacy, retail pharmacies and telehealth providers’ partner pharmacies fill it.
Timeline
What has changed for Foundayo, and when?
The dates that matter for Foundayo’s price and coverage, newest first, each with its source.
Coming up: the temporarily reduced LillyDirect prices for 2.5 mg ($149) and 5.5 mg ($199) run through this date, Lilly says. LillyDirect
We re-read LillyDirect’s self-pay prices: $149 to $299 a month by dose. At 14.5 mg and 17.2 mg, $299 needs a refill within 45 days. LillyDirect
Medicare’s
GLP-1 Bridge opened: a $50 copay for eligible Part D enrollees, with prior authorization, through December 31, 2027. CMSThe FDA approved Foundayo (orforglipron), a once-daily
GLP-1 pill, for adults with obesity, or overweight with a weight-related condition. FDA
Results
How much weight do people lose on Foundayo?
- 12.4%average weight loss on the highest dose, for people who stayed on it
- 27.3 lbsaverage loss on the highest dose (0.9% and 2.2 lbs on placebo)
- 72 weekslength of the ATTAIN-1 trial, about 3,100 adults
Counting everyone who started, whether or not they finished, people on the highest dose lost 11.1% (25 pounds), compared with 2.1% on placebo. Foundayo also lowered waist size, non-HDL cholesterol, triglycerides and blood pressure in the trials.
For context, people on the highest dose of Zepbound lost 20.9% over 72 weeks in SURMOUNT-1, and people on Wegovy lost 14.9% over 68 weeks in STEP 1. Those are different trials with different people, not head-to-head comparisons, and none of them studied compounded medicines.
Compare
Foundayo vs. the Wegovy pill vs. a weekly shot
| Option | How often | Food and water | Self-pay price | FDA-approved |
|---|---|---|---|---|
| Foundayo (orforglipron), Lilly | Daily pill | Any time, with or without food | $149 to $299 a month | Yes |
| Wegovy pill (semaglutide), Novo Nordisk | Daily pill | Comes with food and water rules | $149 to $299 a month by dose | Yes |
| Zepbound (tirzepatide), Lilly | Weekly shot | Any time | $299 to $449 per 28 days by dose, $449 from 7.5 mg with refills within 45 days ($499 to $699 if late) | Yes |
| Compounded semaglutide at NexLife | Weekly shot | Any time | $119 a month on a 12-month plan, $139 month to month, at every dose Pay less elsewhere? Matched† | No |
Foundayo and Zepbound prices from LillyDirect, read November 1, 2026; Wegovy pill prices from our price index, checked November 1, 2026.
More on choosing a format:
Safety
Foundayo side effects
The most common side effects are nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, headache, a swollen belly, tiredness, belching, heartburn, gas and hair loss.
- Like other
GLP-1 medicines, Foundayo carries a warning about thyroid tumors, including cancer. Don’t take it if you or your family have had medullary thyroid carcinoma, or if you have MEN 2 - Serious side effects can include pancreatitis, gallbladder problems, severe stomach problems, dehydration that harms the kidneys, and low blood sugar when taken with insulin or a sulfonylurea
- Birth control pills may not work as well: Lilly says to talk to your provider about a backup method for 30 days after starting and after each dose increase
“The labeling for Foundayo includes a boxed warning for thyroid C-cell tumors.”
U.S. Food and Drug Administration, FDA Approves First New Molecular Entity Under National Priority Voucher Program
Report side effects to the FDA at
Getting it
How to get Foundayo
See a prescriber.
Your own doctor or a telehealth provider decides if Foundayo is right for you.
Get it filled.
LillyDirect’s own pharmacy, a retail pharmacy or a telehealth provider’s partner pharmacy.
Use your savings.
Self-pay prices apply automatically at LillyDirect. With commercial coverage, Lilly’s $25 savings card may lower the cost.
Refill on time.
At 14.5 mg and 17.2 mg, refilling within 45 days keeps the $299 price.
At NexLife
Foundayo alternative: a weekly injection at one flat price
If you’d rather take a weekly weight-loss injection, NexLife offers two. Compounded semaglutide is $119 a month and compounded tirzepatide $139 on 12-month plans. Month to month, they’re $139 and $169. Both are all in, at every dose, with no membership.
Vial math
How many units is your tirzepatide or semaglutide dose?
On a compounded vial, the units depend on its strength. Here are the label doses at example strengths, with the math to check your own.
Tirzepatide
| Dose | mL at 25 mg/mL | Units (U-100) | On the label |
|---|---|---|---|
| 2.5 mg | 0.1 mL | 10 units | Starting dose, for 4 weeks |
| 5 mg | 0.2 mL | 20 units | A maintenance dose |
| 7.5 mg | 0.3 mL | 30 units | A step up |
| 10 mg | 0.4 mL | 40 units | A maintenance dose |
| 12.5 mg | 0.5 mL | 50 units | A step up |
| 15 mg | 0.6 mL | 60 units | The maximum, and a maintenance dose |
The math: mL = dose ÷ strength (mg per mL), and units = mL × 100. At 25 mg/mL, 10 mg is 10 ÷ 25 = 0.4 mL, or 40 units.
Semaglutide
| Weeks | Weekly dose | At 2.5 mg/mL | At 5 mg/mL |
|---|---|---|---|
| 1 to 4 | 0.25 mg | 0.1 mL (10 units) | 0.05 mL (5 units) |
| 5 to 8 | 0.5 mg | 0.2 mL (20 units) | 0.1 mL (10 units) |
| 9 to 12 | 1 mg | 0.4 mL (40 units) | 0.2 mL (20 units) |
| 13 to 16 | 1.7 mg | 0.68 mL (68 units) | 0.34 mL (34 units) |
| 17 onward | 2.4 mg | 0.96 mL (96 units) | 0.48 mL (48 units) |
The math: mL = dose ÷ strength (mg per mL); units = mL × 100. At 2.5 mg/mL, 1 mg is 1 ÷ 2.5 = 0.4 mL, or 40 units. At 5 mg/mL, the same 1 mg is 0.2 mL, or 20 units.
25 mg per mL is an example only: it’s the strength of the 15 mg multi-dose vial on Zepbound’s label (15 mg per 0.6 mL). Read the strength on your own vial’s label; your provider sets your dose, in steps at least 4 weeks apart. Every step: the tirzepatide dosage chart. Both strengths are examples only. The same dose is a different number of units at a different strength, so read the strength on your own vial’s label. Your prescription sets your dose and schedule, which may differ from these label steps. Every step: the semaglutide dosage chart.
What would you pay with NexLife?
Tap where you are now. We’ll show your NexLife price next to it, or tell you we’ll match it.
Pick one above to see your price.
Prices from each provider’s own site, checked November 1, 2026. Brand-name and compounded medications are different products: compounded medications aren’t FDA-approved, and a provider prescribes one only when it offers a significant difference for you. Price Match Guarantee† terms apply.
What does NexLife cost?
One flat price at every dose.
No membership fee. Provider care, a nutrition plan, coaching and shipping are included. Paying less with another licensed provider? We match your regular monthly price.†
GIP + 12-month plan $139/mo
Tirzepatide
Weekly and dual-action. Care, coaching and shipping included. On a 12-month plan; $169/mo month to month.
Check my eligibilityCompounded, not FDA-approved · Not prescribed? No charge for medication
12-month plan $119/mo
Semaglutide
Weekly
Compounded, not FDA-approved · Not prescribed? No charge for medication
Compounded, not FDA-approved. A licensed provider prescribes it only when it offers a significant difference for you. Vials shown are illustrations. Always use the strength on your pharmacy’s label. Every plan and price · Price Match Guarantee† terms
The NexLife Price Match Guarantee†
Paying less elsewhere?
Keep your price. Upgrade your care.
Already on compounded tirzepatide or semaglutide? Pay less with another licensed U.S. telehealth provider or clinic, and we match your regular monthly price for as long as your plan stays active.† Plus a provider who follows your dose, a nutrition plan, a coaching call and real people 24/7.
- 1Send a receipt from the last 60 days
- 2A NexLife provider reviews your prescription
- 3Pay your matched price, at every dose
Locked while your plan is activeSame price at every doseNo membership fee
†Terms: see the Price Match Guarantee† details below. Compounded medications aren’t FDA-approved; a provider prescribes one only when it offers a significant difference for you.
Foundayo: your questions
Fair questions about NexLife
- Will my price go up with my dose?
- No. You pay the same at every dose.
- What if I’m not prescribed?
- You aren’t charged for medication.
- Can I cancel?
- Yes, by email. It takes effect 30 days after we receive it. Plans renew until you cancel; our cancellation policy has the details.
- Do I need insurance?
- No. Pay with an HSA or FSA card, or with Affirm, Klarna or Afterpay at checkout.
What is Foundayo?
Foundayo (orforglipron) is Eli Lilly’s once-daily
Is Foundayo FDA-approved?
Yes. The FDA approved it on April 1, 2026, for adults with obesity, or overweight with weight-related medical problems, alongside diet and physical activity. The FDA describes it as a
How much does Foundayo cost without insurance?
$149 to $299 a month at LillyDirect: $149 at 0.8 mg and 2.5 mg, $199 at 5.5 mg, and $299 from 9 mg to 17.2 mg (checked November 1, 2026). The 2.5 mg and 5.5 mg prices are temporarily reduced through December 31, 2026. At the two highest doses, $299 requires a refill within 45 days.
What are the Foundayo doses?
Six tablet strengths: 0.8 mg (the starting dose), 2.5 mg, 5.5 mg, 9 mg, 14.5 mg and 17.2 mg. You start at 0.8 mg and step up as your provider directs. You take one tablet a day, swallowed whole, with or without food. Self-pay, it’s $149 to $299 a month by dose.
Does insurance or Medicare cover Foundayo?
It depends on your plan. With commercial coverage, Lilly’s savings card can bring Foundayo to as little as $25 for a 1-, 2- or 3-month supply (government plans excluded). On Medicare Part D, eligible enrollees can get it for $50 a month through the
How much weight can you lose on Foundayo?
In the 72-week ATTAIN-1 trial of about 3,100 adults, people on the highest dose who stayed on treatment lost 12.4% of their body weight on average (27.3 pounds), compared with 0.9% on placebo. Counting everyone who started, it was 11.1%. Results vary from person to person.
What’s the difference between Foundayo and the Wegovy pill?
Both are daily
Is Foundayo as effective as Zepbound?
No trial has compared them directly. On Foundayo’s highest dose, people in the 72-week ATTAIN-1 trial lost 12.4% if they stayed on treatment, or 11.1% counting everyone who started. On Zepbound’s highest dose, people lost 20.9% over 72 weeks in SURMOUNT-1. Different trials, different people, and neither studied compounded tirzepatide.
Can you take Foundayo with Zepbound or Wegovy?
No. The FDA says Foundayo “should not be used in combination with another
What are Foundayo’s side effects?
Most often nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, headache, tiredness and gas. Serious ones can include pancreatitis, gallbladder problems and dehydration that harms the kidneys. Its label has a boxed warning for thyroid C-cell tumors: don’t take it if you or your family have had medullary thyroid carcinoma, or if you have MEN 2.
What happens if you don’t refill Foundayo within 45 days?
At 14.5 mg and 17.2 mg, regular prices apply instead of $299, the Foundayo Self-Pay Journey Program price that needs a refill within 45 days. At launch, The New York Times and CNBC reported that regular price as $349. Refilling on time keeps the $299 price.
How do you pronounce Foundayo?
Foundayo is said fown-DAY-oh. It’s the brand name for orforglipron, a once-daily GLP-1 pill from Eli Lilly, the maker of Zepbound. The FDA approved it on April 1, 2026, for adults with obesity, or overweight with a weight-related medical problem.
Does Foundayo affect birth control pills?
It can. Birth control pills may not work as well with Foundayo, so Lilly says to talk to your provider about a backup method for 30 days after starting and after each dose increase.
Important safety information
Compounded tirzepatide and semaglutide are not FDA-approved, and the FDA hasn’t reviewed them for safety, effectiveness or quality. A provider prescribes them only when they offer a significant difference for you compared with an FDA-approved product. Both medicines may cause thyroid tumors, including cancer: don’t use either if you or a family member has had medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Read the full safety information
In studies with rodents, both medicines caused thyroid tumors; it isn’t known whether they cause them in people. Tell your provider if you notice a lump or swelling in your neck, hoarseness, trouble swallowing or shortness of breath. Serious side effects can include inflammation of the pancreas (pancreatitis), gallbladder problems, low blood sugar (especially with insulin or sulfonylureas), kidney problems from dehydration, severe stomach problems, serious allergic reactions, vision changes in people with type 2 diabetes, and a faster heart rate. Tell your care team before any surgery or procedure that uses anesthesia or deep sedation. Don’t combine either medicine with other
Tirzepatide can make birth control pills less effective: switch to a non-oral method, or add a barrier method such as condoms, for 4 weeks after you start and for 4 weeks after each dose increase. Both medicines may harm an unborn baby. Semaglutide should be stopped at least 2 months before a planned pregnancy. Tell your provider right away if you’re pregnant, planning to be, or breastfeeding.
This is a summary, not the complete safety information. Read the full Prescribing Information for FDA-approved tirzepatide (Zepbound) and semaglutide (Wegovy), and talk with your provider. You can report side effects to the FDA at
† NexLife Price Match Guarantee: for new NexLife members switching from a licensed U.S. telehealth provider or clinic with an active prescription for compounded tirzepatide or semaglutide. We match your regular all-in monthly price there (medication plus any required membership, program or visit fee, on a month-to-month plan); first-month offers, coupons, referral credits and prepaid multi-month rates aren’t matched. Proof from the last 60 days required. A licensed provider must determine that treatment is right for you. Not open to people with Medicare, Medicaid or TRICARE coverage. Full terms.
About NexLife. NexLife is a telehealth and care-coordination platform. Care is delivered through affiliated, physician-owned medical groups, and licensed providers decide whether treatment is right for you. NexLife doesn’t make or compound medication: state-licensed partner pharmacies fill each prescription, and we coordinate the rest. Available only in states where our affiliated providers are licensed.
“Compounded drugs are not FDA-approved. This means that FDA does not verify the safety, effectiveness or quality of compounded drugs before they are marketed.”
Who wrote and medically reviewed this page?
Leads the NexLife Medical Team, which writes and medically reviews NexLife’s guides, including this one.
Foundayo’s approval, label summary and ATTAIN-1 results on Lilly’s own pages, read November 1, 2026; LillyDirect prices re-read November 1, 2026
- Every fact, sourced. Each price and rule links to the page it comes from.
- How we make money. NexLife is a telehealth and care-coordination platform. We earn revenue when people join NexLife.
- Corrections, fast. See something wrong or out of date? Email care@nexlife.us and we’ll fix it.
Paying less elsewhere? We match it.†
Prefer one flat price for a weekly shot?
Compounded semaglutide at NexLife is $119 a month on a 12-month plan, or $139 month to month, at every dose. A licensed provider decides if it’s right for you.
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Compounded medications aren’t FDA-approved. A provider prescribes one only when it offers a significant difference for you.
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- 2A licensed provider decides
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- 3We ship it, then stay with you
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Sources
- Eli Lilly and Company. FDA approves Lilly’s Foundayo (orforglipron), news release (April 1, 2026).
- Eli Lilly and Company. Foundayo through LillyDirect: self-pay prices by dose. Read November 1, 2026.
- Eli Lilly and Company. How much should I expect to pay for Foundayo? Read November 1, 2026.
- The New York Times. F.D.A. approves new Eli Lilly weight-loss pill, Foundayo (April 1, 2026).
- CNBC. Eli Lilly
GLP-1 pill Foundayo approved for obesity (April 1, 2026). - KFF. What to know about the BALANCE Model and the Medicare
GLP-1 Bridge (updated May 11, 2026). - The New England Journal of Medicine. Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1), 2022.
- The New England Journal of Medicine. Once-weekly semaglutide in adults with overweight or obesity (STEP 1), 2021.
- Eli Lilly and Company. Zepbound through LillyDirect: self-pay prices for the KwikPen and single-dose vials. Read November 1, 2026.
- Novo Nordisk. What to pay for Wegovy.
- NexLife. Compounded semaglutide plans.
- NexLife. Compounded tirzepatide plans.
- U.S. Food and Drug Administration. FDA’s concerns with unapproved
GLP-1 drugs used for weight loss. - Eli Lilly and Company. Zepbound (tirzepatide) prescribing information.
- Novo Nordisk. Wegovy (semaglutide) prescribing information.
- LegitScript. LegitScript certification record for NexLife.us.
- Ro: weight loss program pricing. Checked November 1, 2026.
- Hims: Zepbound KwikPen. Checked November 1, 2026.
- Hims: Wegovy pill and pen, with membership. Checked November 1, 2026.
- Mochi Health: FAQs (membership and medication prices). Checked November 1, 2026.
- Embody: compounded tirzepatide, one-month supply. Checked November 1, 2026.
- Embody: compounded semaglutide, one-month supply. Checked November 1, 2026.
- U.S. Food and Drug Administration. FDA Approves First New Molecular Entity Under National Priority Voucher Program. April 1, 2026.
- Centers for Medicare & Medicaid Services. Medicare GLP-1 Bridge. Read November 2, 2026.